Anti-Virulence Activity of Selected Natural Products against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a serious opportunistic pathogen in hospitalized patients. The ability of P. aeruginosa to cause a wide range of infections is due to the production of a large array of virulence factors (Balasubramanian et al., 2013). Pseudomonas aeruginosa is highly adaptable and have diverse phenotypic characteristics, to inhabit various environmental conditions (Yosuke and Yutaka, 2013). Plant extracts of many plants exhibit antibacterial, antifungal and insecticidal properties under laboratory trails (Okigbo and Ogbonnaya, 2006 and Shariff et al., 2006). The selection of crude plant extracts for screening programs has the potential of being more successful in its initial steps than the screening of pure individual compounds (Uniyal et al., 2006). Inhibition of bacterial QS can prevent the development of bacterial virulence and successful establishment of infections (Schauder and Bassler, 2001 and Robert et al., 2005). Selected natural products which characterized by QSI in their components will be prepared, extracted and investigated their anti pseudomonal activity against MDR isolates. Furthermore, the effect of the tested natural products/extracts on International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 1 (2017) pp. 396-410 Journal homepage: http://www.ijcmas.com